Leap of Faith
Start to make trouble in Faith's territory, and you'll get the local Mark of Inevitable Doom. In this case, a blessing.
As with the other inescapable story missions, you're best off just biting the bullet. Speak to Faith when she appears in hallucination form.
This begins a long cutscene in which Faith tells you about how she was saved from addiction to find peace with herself, and also to become a mass-murderer.
When you regain 'control,' you'll find yourself standing on a high ledge. Your only choice is to jump - no amount of waiting will dispel the phantasm.
You also can't use your wingsuit or parachute, it turns out. Still, you survive the jump without any broken bones, or other lasting damage, and the mission completes as you awake.